Chevron Left
Back to Finding Mutations in DNA and Proteins (Bioinformatics VI)

Learner Reviews & Feedback for Finding Mutations in DNA and Proteins (Bioinformatics VI) by University of California San Diego

4.7
stars
56 ratings

About the Course

In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins. In the first half of the course, we would like to ask how an individual's genome differs from the "reference genome" of the species. Our goal is to take small fragments of DNA from the individual and "map" them to the reference genome. We will see that the combinatorial pattern matching algorithms solving this problem are elegant and extremely efficient, requiring a surprisingly small amount of runtime and memory. In the second half of the course, we will learn how to identify the function of a protein even if it has been bombarded by so many mutations compared to similar proteins with known functions that it has become barely recognizable. This is the case, for example, in HIV studies, since the virus often mutates so quickly that researchers can struggle to study it. The approach we will use is based on a powerful machine learning tool called a hidden Markov model. Finally, you will learn how to apply popular bioinformatics software tools applying hidden Markov models to compare a protein against a related family of proteins....

Top reviews

TK

Jun 28, 2016

One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.

EJ

Jul 31, 2021

Great course! It opened my mind on the capabilities of algorithms beyond its intended purpose.

Filter by:

1 - 13 of 13 Reviews for Finding Mutations in DNA and Proteins (Bioinformatics VI)

By Samuel C

Sep 16, 2018

By Jason M

Jun 23, 2020

By Mohamed A

Aug 14, 2017

By Tamas K

Jun 29, 2016

By Edgardo P F J

Jul 31, 2021

By Ramiz G

Apr 14, 2020

By Sakshar C

Jul 1, 2020

By Zack X

Jul 21, 2019

By Arsham M N

Apr 1, 2022

By Mare B

May 16, 2020

By Thomas L

Jul 17, 2017

By Thomas G

Dec 20, 2018

By Weidong X

Feb 27, 2017